Made the switch to use Safari as my default browser last week, switching from Chrome. It’s taken a little bit of adjusting, but so far so good. I’ve found that 1Password integrates much better, Safari is much better at not hogging system resources and when I get a security code vis SMS, it pops up as a suggestion. Also switched to using duckduckgo as my default search engine and that’s working out well too.
There are a few sites that don’t play nicely with Safari, Microsoft admin portal is one notable one and YNAB Toolkit (a chrome extension) of course doesn’t work. I will have chrome installed for these but do my best to limit my ‘Chrome time’.